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The relationship between cancer and blood vessels ?span style="font:7.0pt "Times New Roman""> The blood vessel is the means of nutrition and metabolism of the cancer. ?span style="font:7.0pt "Times New Roman""> The blood vessel is the fast, convenient and direct way to transform the cancer. ?span style="font:7.0pt "Times New Roman""> The growth and metastasis of the original cancer are both dependent on angiogenesis. Anti-angiogenic therapy ?span style="font:7.0pt "Times New Roman""> Recurrence and metastasis are the basic reasons for the failure of cancer treatment. ?span style="font:7.0pt "Times New Roman""> The blood vessel system of tumors has already become a promising target for anticancer treatment. ?span style="font:7.0pt "Times New Roman""> Anti-angiogenic therapy is one way to cut off the supply of nutrition to the cancer. The other is to block or obstruct the transfer to other areas (metastasis). It has become a very important element in the synthetic treatment of cancer. The mechanism of RG3 Rg3 is the first new anti-angiogenic inhibitor to enter clinical use. It can work on many aspects of the angiogenic process. Some of the mechanisms are described below; ?span style="font:7.0pt "Times New Roman""> Inhibit the cancer cell from secreting growth factors for blood vessels, including VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor), reducing the production of epithelial cells of the blood vessels. ?span style="font:7.0pt "Times New Roman""> Block the biological effect of the growth factor on the vessel. Reduce the rate of combination on bFGF receptor (bFGFR). ?span style="font:7.0pt "Times New Roman""> Inhibit the expression levels of MMPs. Matrix metalloproteinases are a family of enzymes that eat through the barriers that hold cells in place. They are involved in tumor growth, angiogenesis (development of new blood vessels), invasion, and the spread of cancer (metastasis). Research shows blocking MMP activity reduces tumor growth and prolongs the survival of treated animals. ?span style="font:7.0pt "Times New Roman""> Interfere with the reaction between epithelial cells and EMC to prevent the formation of blood vessel nets of cancer.
RG3 inhibition of blood vessel formation in gastric cancer
Before the operation the gastric cancer patient took oral 20mg Rg3 per dose, 3 times per day for 2 weeks. After the operation pathological samples were obtained and assayed for expression of MVD, VEGF and bFGF. The samples were compared to a control group who had not taken the Rg3. The results showed the Rg3 had a definite effect on the inhibition of blood vessels in the cancer. The mechanism may be related to the inhibition of expression of VEGF and bFGF.
Data from Chinese National Surgical Periodical
The experimental model is transformation of gastric cancer in mice. Rg3 was given orally at levels of 2.5mg/Kg, 5.0mg/Kg and 10.0mg/Kg, 1 time per day. The control group was given the same amounts of 0.9% physiological saline 1 time per day. Assays were performed on the inhibition of cancer rate, inhibition of liver metastasis and the inhibition of peritoneum metastasis. Rg3 inhibits the formation of blood vessels in breast cancer
The comparison between the weight of breast cancer and MVD on different treatment combinations. The results showed: ?span style="font:7.0pt "Times New Roman""> Rg3 has a significant inhibitory effect on antiangiogenic effects and MVD in breast cancer. ?span style="font:7.0pt "Times New Roman""> When combined with CTX treatment the above results were more significant. ?span style="font:7.0pt "Times New Roman""> It must be pointed out that when Rg3 is used with combination therapy not only is the mitigation rate improved but also significant improvement is seen in the inhibition of antiangiogenesis, greater prevention of recurrence and metastasis thus improving the overall prognosis
The immune group SP method was used to assay the level of VEGF protein expression in the breast cancer tissue. The result showed that when compared with the control group Rg3 has significant inhibitory effect on the protein expression of the VEGF protein causing a reduction in microcapillary density in the cancer tissue and inhibiting the formation of new blood vessels. Rg3 inhibition of bladder cancer transfer to the lung
This experiment examines the influence of Rg3 on the induction of angiogenesis. There was an observed statistically significant (p<0.5) effect which was dose dependant with more angiogenesis observed with decreasing Rg3 concentration.
This experiment examines the influence of Rg3 on the amount of metastasis. There was an observed statistically significant (p<0.01) effect which was dose dependant with more metastasis observed with decreasing Rg3 concentration.
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